Resumen:
eurons are highly polarized cells requiring precise regulation of trafficking and targetingof membrane proteins to generate and maintain different and specialized compartments, such as axonsand dendrites. Disruption of the Golgi apparatus (GA) secretory pathway in developing neuronsalters axon/dendritic formation. Therefore, detailed knowledge of the mechanisms underlyingvesicles exiting from the GA is crucial for understanding neuronal polarity. In this study, we analyzedthe role of Brefeldin A-Ribosylated Substrate (CtBP1-S/BARS), a member of the C-terminal-bindingprotein family, in the regulation of neuronal morphological polarization and the exit of membraneproteins from the Trans Golgi Network. Here, we show that BARS is expressed during neuronaldevelopment in vitro and that RNAi suppression of BARS inhibits axonal and dendritic elongationin hippocampal neuronal cultures as well as largely perturbed neuronal migration and multipolarto-bipolar transition during cortical developmen